TABLE 1.

Sensitivity and specificity of surveillance and diagnostic tools for cholangiocarcinoma in patients with PSC

Test modality	Sensitivity, %	Specificity, %
Surveillance
CA 19-9	Varies widely based on the cutoff value used
MRCP	89	75
Diagnosis
Brush cytology	18–40	~100
FISH	41	98
NGS	Unknown

Abbreviations: FISH, fluorescent in situ hybridization; NGS, next-generation sequencing; MRCP, magnetic resonance cholangiopancreatography.