Table 2.
The mean values of TOS in various biological fluid samples between healthy controls and patients with periodontitis in the included studies of quantitative synthesis.
| Study name | Country | Study design | Criteria | Age years case/control mean ± SD or range | Sample type | Unit of measurement | Periodontitis | Control | p-Value | ||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Mean ± SD or median (upper–lower value) | Sample size (M/F) | Mean ± SD median (upper– lower value) | Sample size (M/F) | ||||||||
| Akalın et al. [9] | Turkey | CC | Armitage [47] | 40.66 ± 5.31/38.5 ± 6.10 | Serum | µmol | 22.5 ± 17.21 | 36 (19/17) | 13.77 ± 2.381 | 28 (13/15) | <0.05 |
| Saliva | µmol | 6.03 ± 1.37 | 4.16 ± 0.63 | <0.05 | |||||||
| GCF | µmol | 39.2 ± 5.95 | 31.4 ± 5.54 | <0.05 | |||||||
| Wei et al. [16] | China | PS | Armitage [47] | 40.1 ± 7.3/42.1 ± 7.7 | Serum | mmol | 24.8 ± 18.53 | 48 (27/21) | 19.21 ± 16.246 | 35 (19/16) | <0.05 |
| Saliva | mmol | 9.12 ± 1.77 | 6.75 ± 1.02 | <0.05 | |||||||
| GCF | mmol | 50.9 ± 6.33 | 42.76 ± 7.94 | <0.05 | |||||||
| Esen et al. [19] | Turkey | CS | AL ≥ 4 mm and PPD ≥ 5 mm | 42.85 ± 9.6/40.05 ± 9.8 | Serum | µmol H2O2 equiv./l | 7.115 (4.920– 8.055) | 20 (4/16) | 6.935 (5.655– 8.755) | 20 (4/16) | 0.920 |
| GCF | 0.285 (0.070–0.360) | 0.010 (0.010– 0.415) | 0.030 | ||||||||
| Toker et al. [21] | Turkey | Interventional study | CAL > 30% of sites; PPD ≥ 5 mm | 38.7 ± 5.9/38.0 ± 7.2 | GCF | µmol H2O2 Eq/l | 10.06 ± 0.22 | 15 (7/8) | 10.4 ± 0.48 | 10 (6/4) | <0.05 |
| Akpinar [22] | Turkey | Interventional | Armitage [47] | 37.7 ± 5.9/37.0 ± 7.4 | GCF | µmol H2O2 equiv./l | (9.4–10.7) 10 | 15 (7/8) | (9.7–11.3) 10.6 | 10 (5/5) | |
| Sezer [24] | Turkey | CS | – | 45.50 ± 7.50/40.75 ± 10.26 | Serum | µmol H2O2 Eq/l | 19.48 ± 7.91 | 20 (6/14) | 21.47 ± 7.39 | 20 (6/14) | |
| Baltacıoğlu et al. [26] | Turkey | CS and CC | Armitage [47] | 32.55 ± 5.32/30.10 ± 4.06 | Serum | µmol | 16.8 ± 2.467 | 33 (16/17) | 13.77 ± 0.567 | 30 (16/14) | <0.05 |
| Saliva | µmol | 6.27 ± 0.844 | 4.167 ± 0.444 | <0.05 | |||||||
| GCF | µmol H2O2 Eq/l | 27.5 ± 4.96 | 30 | 19.75 ± 3.46 | 28 | <0.05 | |||||
| Bostanci [27] | Turkey | Interventional studies | Armitage [47] | 38.80 ± 4.87/37.33 ± 5.67 | GCF | µmol H2O2 Eq/l | 9.74 (8.75–12.25) | 15 (6/9) | 5.25(4.05–7.72) | 15 (7/8) | <0.05 |
| Serum | 4.2 (3.25–6.85) | 3.86(2.24–5.25) | >0.05 | ||||||||
| Kose et al. [28] | Turkey | Comparative study | Armitage [47] | 27–51 years | Serum | µmol H2O2 Eq/l | 16 ± 4.01 | 22 (11/11) | 12.19 ± 2.77 | 22 (12/10) | <0.05 |
| Saliva | 6.8 ± 3.49 | 4.41 ± 1.54 | <0.05 | ||||||||
| Vincent et al. [42] | India | Comparative study | Armitage [48] | 25–65 years | GCF | µmol/l | 9.08 ± 3.7 | 20 (10/10) | 5.2 ± 1.3 | 20 (11/9) | <0.001 |
The method utilized for the assessment of TOS values in various biological samples was Erel [53]. SD, standard deviation; Cont, control; H2O2, hydrogen peroxide; Eq, equivalent; CC, case–control; PS, prospective study; CS, cross-sectional study.