Table 4.
TRAEs of any grade occurring in ≥20%.
| Total n = 59 No. (%) |
Cohort A n = 31 No. (%) |
Cohort B n = 28 No. (%) |
||||
|---|---|---|---|---|---|---|
| TRAEs | All Grades | Grade ≥3 | All Grades | Grade ≥3 | All Grades | Grade ≥3 |
| Decreased platelet count | 28 (47.5) | 5 (8.5) | 17 (54.8) | 4 (12.9) | 11 (39.3) | 1 (3.6) |
| Proteinuria | 27 (45.8) | 2 (3.4) | 10 (32.3) | 1 (3.2) | 17 (60.7) | 1 (3.6) |
| Hypertension | 26 (44.1) | 12 (20.3) | 15 (48.4) | 8 (25.8) | 11 (39.3) | 4 (14.3) |
| White blood cell count decreased | 26 (44.1) | 2 (3.4) | 17 (54.8) | 1 (3.2) | 9 (32.1) | 1 (3.6) |
| Weight loss | 24 (40.7) | 1 (1.7) | 15 (48.4) | 1 (3.2) | 9 (32.1) | 0 (0.0) |
| Decreased neutrophil count | 24 (40.7) | 3 (5.1) | 17 (54.8) | 2 (6.5) | 7 (25.0) | 1 (3.6) |
| Alanine aminotransferase increased | 22 (37.3) | 4 (6.8) | 15 (48.4) | 3 (9.7) | 7 (25.0) | 1 (3.6) |
| Aspartate aminotransferase increased | 22 (37.3) | 2 (3.4) | 15 (48.4) | 1 (3.2) | 7 (25.0) | 1 (3.6) |
| Hypothyroidism | 21 (35.6) | 0 (0.0) | 10 (32.3) | 0 (0.0) | 11 (39.3) | 0 (0.0) |
| Blood bilirubin increased | 19 (32.2) | 1 (1.7) | 10 (32.3) | 1 (3.2) | 9 (32.1) | 0 (0.0) |
| Diarrhea | 19 (32.2) | 3 (5.1) | 13 (41.9) | 1 (3.2) | 6 (21.4) | 2 (7.1) |
| Anemia | 17 (28.8) | 0 (0.0) | 12 (38.7) | 0 (0.0) | 5 (17.9) | 0 (0.0) |
| Rash | 15 (25.4) | 4 (6.8) | 12 (38.7) | 3 (9.7) | 3 (10.7) | 1 (3.6) |
| Fatigue | 14 (23.7) | 0 (0.0) | 11 (35.5) | 0 (0.0) | 3 (10.7) | 0 (0.0) |
| Hypoalbuminemia | 13 (22.0) | 0 (0.0) | 3 (9.7) | 0 (0.0) | 10 (35.7) | 0 (0.0) |
| Blood thyroid stimulating hormone increased | 12 (20.3) | 0 (0.0) | 6 (19.4) | 0 (0.0) | 6 (21.4) | 0 (0.0) |
| Decreased appetite | 12 (20.3) | 4 (6.8) | 8 (25.8) | 2 (6.5) | 4 (14.3) | 2 (7.1) |
| Palmar metatarsal redness syndrome | 12 (20.3) | 0 (0.0) | 6 (19.4) | 0 (0.0) | 6 (21.4) | 0 (0.0) |