Table 1.
Patient demographics before and after inverse probability of treatment weighting
| Unweighted | Weighted | |||||
|---|---|---|---|---|---|---|
| Clopidogrel | Ticagrelor | SMD | Clopidogrel | Ticagrelor | SMD | |
| Demographics | ||||||
| n | 13 0194 | 11 0848 | 12 627.03 | 9051.07 | ||
| Age, mean (SD) | 80.01 (8.09) | 77.07 (7.51) | 0.299 | 79.01 (8.61) | 79.11 (7.66) | 0.012 |
| Sex, female | 6318 (47.9) | 5162 (43.6) | 0.087 | 5844.3 (46.3) | 4129.2 (45.6) | 0.013 |
| PRECISE-DAPT score, median [Q1, Q3] | 35.0 [30.00, 42.00] | 32.0 [28.00, 38.00] | 0.282 | 34.00 [29.00, 41.00] | 33.00 [29.00, 40.00] | 0.033 |
| Creatinine clearance (mL/min), median [Q1, Q3] | 45.5 [35.09, 54.80] | 48.9 [40.02, 57.20] | 0.228 | 46.63 [36.21, 56.06] | 47.04 [37.61, 56.12] | 0.022 |
| Prior bleeding | 1580.0 (12.0) | 1328.0 (11.2) | 0.024 | 1556.8 (12.3) | 1086.0 (12.0) | 0.010 |
| Hemoglobin (g/dL), mean (SD) | 130.7 (16.99) | 133.6 (16.68) | 0.172 | 131.48 (17.24) | 132.01 (16.98) | 0.031 |
| Length of stay (days), median [Q1, Q3] | 4.00 [3.00, 7.00] | 4.00 [3.00, 6.00] | 0.153 | 4.00 [3.00, 6.00] | 4.00 [3.00, 6.00] | 0.040 |
| Calender year | 1.607 | 0.777 | ||||
| 2010 | 3237.0 (24.5) | 0.0 (0.0) | 1705.5 (13.5) | 0.0 (0.0) | ||
| 2011 | 3207.0 (24.3) | 36.0 (0.3) | 1708.7 (13.5) | 168.5 (1.9) | ||
| 2012 | 2239.0 (17.0) | 1136.0 (9.6) | 1801.5 (14.3) | 1614.6 (17.8) | ||
| 2013 | 1365.0 (10.3) | 1813.0 (15.3) | 1707.7 (13.5) | 1596.5 (17.6) | ||
| 2014 | 1056.0 (8.0) | 1988.0 (16.8) | 1589.8 (12.6) | 1463.4 (16.2) | ||
| 2015 | 827.0 (6.3) | 2169.0 (18.3) | 1476.6 (11.7) | 1406.4 (15.5) | ||
| 2016 | 695.0 (5.3) | 2372.0 (20.0) | 1399.7 (11.1) | 1438.8 (15.9) | ||
| 2017 | 568.0 (4.3) | 2334.0 (19.7) | 1237.5 (9.8) | 1363.0 (15.1) | ||
| Current smokers | 1364.0 (10.3) | 1504.0 (12.7) | 0.074 | 1443.6 (11.4) | 1032.8 (11.4) | 0.001 |
| Comorbidities | ||||||
| MI | 3962.0 (30.0) | 2525.0 (21.3) | 0.201 | 3317.6 (26.3) | 2198.0 (24.3) | 0.046 |
| CHF | 2304.0 (17.5) | 1173.0 (9.9) | 0.221 | 1853.2 (14.7) | 1212.8 (13.4) | 0.037 |
| Diabetes mellitus | 3526.0 (26.7) | 3133.0 (26.4) | 0.006 | 3413.1 (27.0) | 2431.0 (26.9) | 0.004 |
| Stroke | 1663.0 (12.6) | 1056.0 (8.9) | 0.119 | 1503.3 (11.9) | 990.6 (10.9) | 0.030 |
| Renal failure | 910.0 (6.9) | 572.0 (4.8) | 0.088 | 807.5 (6.4) | 592.1 (6.5) | 0.006 |
| COPD | 1266.0 (9.6) | 1024.0 (8.6) | 0.033 | 1200.4 (9.5) | 854.9 (9.4) | 0.002 |
| Peripheral arterial disease | 1055.0 (8.0) | 690.0 (5.8) | 0.086 | 937.9 (7.4) | 650.6 (7.2) | 0.009 |
| Hypertension | 9202.0 (69.7) | 8244.0 (69.6) | 0.004 | 8894.7 (70.4) | 6458.0 (71.4) | 0.020 |
| Cancer | 635.0 (4.8) | 471.0 (4.0) | 0.041 | 608.7 (4.8) | 437.3 (4.8) | 0.001 |
| Prior medical interventions | ||||||
| CABG | 1537.0 (11.6) | 969.0 (8.2) | 0.116 | 1292.3 (10.2) | 841.2 (9.3) | 0.032 |
| PCI | 2118.0 (16.1) | 1744.0 (14.7) | 0.037 | 1975.8 (15.6) | 1392.9 (15.4) | 0.007 |
| Type of myocardial infarction | ||||||
| STEMI | 3653.0 (27.7) | 4514.0 (38.1) | 0.223 | 4006.4 (31.7) | 2986.1 (33.0) | 0.027 |
| Killip class > 1 | 448.0 (3.4) | 267.0 (2.3) | 0.069 | 374.6 (3.0) | 246.3 (2.7) | 0.015 |
| Medications on admission | ||||||
| Aspirin | 6755.0 (51.2) | 4778.0 (40.3) | 0.219 | 5932.5 (47.0) | 4037.6 (44.6) | 0.048 |
| Beta-blockers | 5759.0 (43.6) | 4290.0 (36.2) | 0.152 | 5210.6 (41.3) | 3578.2 (39.5) | 0.035 |
| Calcium channel antagonists | 3295.0 (25.0) | 3033.0 (25.6) | 0.014 | 3232.1 (25.6) | 2302.6 (25.4) | 0.004 |
| Digoxin | 122.0 (0.9) | 37.0 (0.3) | 0.078 | 87.7 (0.7) | 48.3 (0.5) | 0.021 |
| ACE-inhibitor or ARB | 5517.0 (41.8) | 4900.0 (41.4) | 0.009 | 5347.6 (42.4) | 3783.7 (41.8) | 0.011 |
| Diuretics | 4284.0 (32.5) | 2876.0 (24.3) | 0.183 | 3732.9 (29.6) | 2516.9 (27.8) | 0.039 |
| Statins | 4352.0 (33.0) | 3459.0 (29.2) | 0.082 | 3995.0 (31.6) | 2706.3 (29.9) | 0.038 |
| In-hospital treatments | ||||||
| PCI | 7335.0 (55.6) | 9976.0 (84.2) | 0.656 | 8528.9 (67.5) | 6454.0 (71.3) | 0.082 |
| Coronary angiography | 9204.0 (69.8) | 10 945.0 (92.4) | 0.603 | 10 026.8 (79.4) | 7412.3 (81.9) | 0.063 |
| Inotropes | 217.0 (1.6) | 275.0 (2.3) | 0.049 | 249.5 (2.0) | 195.2 (2.2) | 0.013 |
| Diuretics | 2879.0 (21.8) | 2111.0 (17.8) | 0.101 | 2662.2 (21.1) | 1821.2 (20.1) | 0.024 |
| Medications on discharge | ||||||
| Beta-blockers | 11 542.0 (87.5) | 10 464.0 (88.3) | 0.026 | 11 049.0 (87.5) | 7925.6 (87.6) | 0.002 |
| Calcium channel antagonists | 2943.0 (22.3) | 2570.0 (21.7) | 0.015 | 2844.4 (22.5) | 2035.7 (22.5) | 0.001 |
| Digoxin | 111.0 (0.8) | 28.0 (0.2) | 0.083 | 74.2 (0.6) | 35.6 (0.4) | 0.028 |
| ACE-inhibitor or ARB | 9989.0 (75.7) | 9909.0 (83.6) | 0.198 | 9923.9 (78.6) | 7224.0 (79.8) | 0.030 |
| Diabetes medications | 2646.0 (20.1) | 2407.0 (20.3) | 0.007 | 2557.1 (20.3) | 1838.7 (20.3) | 0.002 |
| Statins | 11 118.0 (84.3) | 11 131.0 (93.9) | 0.315 | 11 092.3 (87.8) | 8015.7 (88.6) | 0.022 |