Extended Data Table 1.

Summary of MCM and outcome measures following IV BCG vaccination and Mtb challenge

Historical controls in the SIV/Unvax group include: 6016, 6416, 6716, 12415, 12715, 13015, and 13115. Age is indicated as years (y) and months (m). For ESR, GA, and BAL, time point indicated post Mtb infection, unless otherwise stated. Total Mtb CFU limit of detection (LOD) is < 100 CFU per animal. One haplotype from 15819 expressed the M3 class I A alleles, but M1 class I B and II alleles - the M3 and M1 class I A regions share the major MHC class I A allele Mafa-A1*063, but the signal peptide sequence differs by one amino acid between the two haplotypes54. The recombinant haplotype of 171-19 contains M1 MHC class I A alleles and M4 MHC class I B and class II alleles. The recombinant haplotype of 131-15 contains M1 MHC class I B alleles and M2 MHC class I A and class II alleles.