Table 4.

Effect of metformin on gene expression of fatty acid transporters and endothelial lipase in human trophoblasts

Gene	0.01 mmol/l metformin	p value	n	0.1 mmol/l metformin	p value	n
FATP1	3520±583	0.77	30	3841±572	0.04	30
FATP2	2195±303	0.91	30	3611±451	0.02	30
FATP3	2894±368	0.82	30	2889±364	0.65	30
FATP4	8377±876	0.92	32	11033±949	0.03	31
FATP5	821±195	0.77	32	679±137	0.91	32
FATP6	29,013±3748	0.99	32	34,663±4871	0.53	32
LIPG	8393±727	0.21	31	8001±1034	0.83	31

Copy number is displayed as n±SE. n represents number of placentas per group, run in duplicate

p values are derived from mixed-effects linear regression analysis with treatment group included as a fixed effect and placenta of origin as a random effect, with the vehicle-treated group as the referent