Table 2.
Postmortem macroscopic and neurohistologic findings in initial prospective IPV case series
| Case | Age (decade) | Neck compression | Torso/extremity injury | Neuropathology | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Ex vivo imaging | Brain weight (g) | TBI | DAI | WM microglia/ macrophages | Perivascular/ parenchymal iron | Vascular disease | CTE-NC | AD-NC | LBD | ARTAG | CAA | Other | ||||
| NY1 | 3rd | – | R | – | 1100a | R | – | + | – | – | – | – | – | + | – | Slight chronic meningitis |
| NY2 | 3rd | – | – | + | 1010a | O | – | – | – | Old cortical infarctb | – | – | – | – | – | HIVE and leukoencephalopathyb |
| NY3 | 3rd | – | O | + | 1318 | – | + | – | + | – | – | – | – | – | – | – |
| NY4 | 4th | O | O/R | – | 1300 | O | – | + | + | – | – | – | – | – | – | Cortical microdysgenesis; possible PART |
| NY5 | 4th | – | R | – | 1170a | R | + | + | + | – | – | – | – | – | – | Possible PART |
| NY6 | 4th | – | O | + | 1330 | O/R | + | + | + | Perivascular edema and mineralization in WMb | – | – | – | – | – | – |
| NY7 | 4th | O/R | R | – | 1380 | R | – | + | + | – | – | – | – | – | – | – |
| NY8 | 4th | R | R | + | 1352 | O | + | + | + | – | – | – | – | – | – | – |
| NY9 | 5th | – | R | – | 1350 | – | + | + | + | Lacune | – | – | – | + | – | |
| NY10 | 5th | – | – | – | 950a | – | + | + | + | – | – | – | – | – | – | Slight chronic meningitis |
| NY11 | 6th | – | – | – | 1360 | O/R | + | + | + | Old and organizing infarcts; acute ischemia | – | – | – | – | – | – |
| NY12 | 6th | – | – | – | 1300 | O/R | + | + | + | Lacune; old cortical infarct | – | – | – | – | – | Mesial temporal sclerosis |
| NY13 | 7th | – | R | – | 1150a | O | + | + | + | Lacune | – | – | – | – | – | – |
| NY14 | 8th | – | – | – | 900a | O | – | + | – | Old cortical microinfarct | – | Low | – | + | + | Remote temporal lobectomy for seizures |
+ assessed and present, – assessed and not present, AD-NC Alzheimer Disease neuropathologic change, 24ARTAG “age-related” tau astrogliopathy, CAA cerebral amyloid angiopathy, CTE chronic traumatic encephalopathy, DAI diffuse (traumatic) axonal injury, HIVE human immunodeficiency virus encephalitis, HS hippocampal sclerosis of aging, NA data not assessed/available, NY# from New York City Office of Chief Medical Examiner, PART Primary “age-related” tauopathy, O old, R recent/acute, SDH subdural hematoma, TBI traumatic brain injury, WM white matter
aAtrophy (brain weight less than expected [1200–1500 g])
bDetected on ex vivo imaging
See text for further explanation and definitions used, and figures for examples. See Supplement for details of findings in archival cohorts