Table 2.
Mechanism of acupuncture on the repair of spinal cord regulation in peripheral nerve injury.
| Study | Model | Acupoints | Acupuncture type/parameter | Major effects |
|---|---|---|---|---|
| Pan et al. (2019) | DPN | BL13, BL20, BL23, LI4, LR3, ST36, SP6 | EA/frequency 3 Hz, 20 min | GRP78↓, caspase-12↓, sciatic nerves cell apoptosis↓ |
| Kim et al. (2009) | Capsaicin-induced secondary hyperalgesia | GB30-GB34, BL40-BL60, GV2-GV6, LI3-LI6, SI3-TE8 | EA/intensity 3 mA, frequency 2/100 Hz, 30 min | Endogenous spinal mu- and delta-opioid receptors↑ |
| Koo et al. (2008) | Ankle sprain | SI6, LI4 | EA/intensity 2 mA, frequency 2/100 Hz, 30 min | Spinal alpha (2)-adrenoceptor↑ |
| Li et al. (2007) | Inflammatory pain | GB30 | EA/intensity 3 mA, frequency 10 Hz, 20 min | Supraspinal neurons↑ |
| Mayer et al. (1977) | Ho-Ku’ | MA/rotated for 2 min out of 5 min, 30 min | Release of an endogenous substance with narcotic analgesic activity↑ |
DPN, diabetic peripheral neuropathy; GRP78, glucose-regulated protein 78.