Fig. 2.

Example of the harmonized representation of transgenic alleles at the Alliance of Genome Resources. a Transgenic alleles of the mTor gene in Drosophila. b Transgenic alleles of the Mtor gene in the laboratory mouse. In the Alliance data model, transgenic alleles are represented by various components that can be populated with information in a species-specific manner which allows for representational consistency and completeness across all model organisms. Allele symbols conform to species-specific nomenclature standards. Transgenic constructs represent the transgene construct independent of the host organism following species-specific guidelines. Expressed components represent the genetic elements expressed by the construct which may be full or partial genes and may include both protein-coding and non protein-coding genes. Knock-down targets are elements in the transgene designed to interfere with the expression of another gene. The regulatory regions component includes genetic elements driving the expression of entities in the construct (e.g., upstream activation sequence, human cytomegalovirus, etc.)