Table 2.
Effect of XL-HA (batch 1) concentration on the dynamic viscoelastic properties and TA removal ability
Sample | Removal | Solidity | Liquidity | Behavior 5 min after injection into BSS | ||
---|---|---|---|---|---|---|
Abilitya (%) | S-index (min) | Tweezers operation | L-index (min) | Injectabilityb | ||
1% HA300 | 0 | Not tried | Impossible | Fluid | Easy | Diffusive |
1% HA-AEA | 0 | Not tried | Impossible | Fluid | Easy | Diffusive |
1% HA-DBCO | 0 | Not tried | Impossible | Fluid | Easy | Diffusive |
0.13% XL-HA | 7 | Not tried | Impossible | Fluid | Easy | Diffusive |
0.65% XL-HA | Not tried | 10.3 | Breakable | 8.3 | Easy | Non-dispersive |
0.76% XL-HAd | 55 | – | Stretchable, breakable | – | Easy | – |
0.86% XL-HA | 45 | 5.4 | Stretchable, breakable | 2.8 | Easy | Non-dispersive |
0.86% XL-HAd | 84 | – | Stretchable, breakable | – | Easy | – |
0.97% XL-HA | 71 | 3.8 | Easy | 1.6 | Easy | Non-dispersive |
1.08% XL-HA | 64 | 2.9 | Easy | 1.2 | Easy | Non-dispersive |
1.19% XL-HA | 87 | 1.8 | Easy | 1.0 | Easy | Non-dispersive |
1.30% XL-HA | 71 | 1.6 | Easy | 0.7 | Easy | Non-dispersive |
1.41% XL-HA | 69 | 1.2 | Easy | 0.4 | Easy | Non-dispersive |
1.51% XL-HA | 76 | 0.8 | Easy | 0.0 | Easy | Thread-shape |
1.62% XL-HA | 66 | 0.3 | Easy | 0.0 | Hard | Thread-shape |
1.73% XL-HA | 59 | 0.0 | Easy | 0.0 | Hard | Thread-shape |
0.78% XL-HA (DS: 0.3)c | 79 | 1.2 | Breakable | 0.0 | Easy | Non-dispersive |
1% HA-cohesive | 0 | Not tried | Impossible | 0.0 | Very hard | Diffusive |
Gel-One | 0 | Not tried | Impossible | 0.0 | Very hard | Diffusive |
Beriplast P; tenfold diluted | 97 | 19 | Stretchable | 0.2 | Easy | Non-dispersive |
a[TA Removal, %] = {[Initial TA, 2 mg] – [TA recovered, mg]}/[2 mg] × 100. Removal ability was measured in each sample three times and the average value was recorded
bInjectability was qualitatively assessed using a 1 ml syringe with an attached 27-gauge needle
cHA derivatives prepared as batch 6 (DS: 0.3) were used for the preparation of 0.78% XL-HA
dProperties assessed 10 min after injection into BSS