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. 2023 Nov 6;13:19231. doi: 10.1038/s41598-023-46016-z

Figure 1.

Figure 1

The effect of dapagliflozin treatment on magnitude of blood pressure in female Dahl SS rats. (A) Schematic representation of the experimental protocol. (B) The mean arterial pressure (MAP) in SS rats after diet change from normal salt (NS, 0.4% NaCl; day 0) to a high salt (HS, 4% NaCl) diet and chronic treatment with the SGLT2 inhibitor (dapagliflozin) or vehicle (C) Changes in MAP in weeks 1, 2, and 3 of Dapa treatment on the HS diet compared to baseline MAP on the NS diet. Systolic (SBP) (D) and diastolic (DBP) (E) blood pressure in SS rats after diet change from normal salt (NS, 0.4% NaCl; day 0) to a high salt (HS, 4% NaCl) diet and chronic treatment with the SGLT2 inhibitor (dapagliflozin) or vehicle. (F) Diurnal blood pressure and (G) heart rate recordings on HS diet over the last three days, each point is a 2-h average. Shaded regions in (F) and (G) indicate the active period for animals (lights were off in the animal facility). For all figures n = 6–7, two-way repeated-measures ANOVA was used, *P < 0.05. ** P < 0.01, *** P < 0.001 are considered statistically significant.