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. 2023 Oct 24;14:1263500. doi: 10.3389/fphys.2023.1263500

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Copyright © 2023 Yee, Hauser, Petrocelli, de Hart, Ferrara, Bombyck, Fennel, van Onselen, Mookerjee, Funai, Symons and Drummond.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Assessment of whole-body physical function before (pre) and after (baseline) exercise training in exercise-trained and sedentary aged mice. (A) Workload capacity, (B) grip strength (normalized to body weight), and rotarod (C) speed (C) and time (D) were evaluated pre and post 12 weeks of treadmill training. Results are expressed as mean fold change from the pre-measurement with standard error of the mean. A paired t-test was used to compare sedentary and exercise-trained groups. ****p < 0.0001, **p ≤ 0.01. Panels (A–D) contain n = 28–32.