Table 3.

Overview of the studies published to date that compare PGT-A with conventional IVF treatment.

RCT	Patients	Controls	Embryo biopsy	Genetic platform	LBR (unless otherwise indicated)	Miscarriage rate
Yang etal. (2012b)	55 good-prognosis patients, 1st IVF cycle Age: 31.2 ± 2.5	48 controls Age: 31.5 ± 2.7	Blastocyst	aCGH	Higher1 38/55 (69.1%) vs 20/48 (41.7%) (P = 0.009) (per ET)	No difference 1/55 (2.6%) vs 2/48 (9.1%) (P = 0.597)
Forman etal. (2013)	89 single euploid blastocyst transfer, normal ovarian reserve, ≤1 previous IVF failure Age: 35.1 ± 3.9	86 double blastocyst transfer Age: 34.5 ± 4.7	Blastocyst	qPCR	No difference2 60.7% vs 65.1% (RR 0.9; 95% CI 0.7 to 1.2) (per ET)	Not reported
Scott etal. (2013)	134 blastocysts/ 72 patients with normal ovarian reserve, ≤1 previous IVF failure Age: 32.2 ± 0.5	163 blastocysts/83 patients Age: 32.4 ± 0.5	Blastocyst	qPCR	Higher 61/72 (84.7%) vs 56/83 (67.5%) (RR 1.26; 95% CI 1.06 to 1.53; P = 0.01) (per ET)	No difference 7/61 (11.5%) vs 14/70 (20.0%); P = 0.2)
Rubio etal. (2017)	538 Day 3 embryos from 138 patients Age: 38–41	581 Day 3 embryos/140 patients Age: 38–41	Day 3	aCGH	No difference 44/138 (31.9%) vs 26/140 (18.6%) (OR 2.381, 95% CI 1.343 to 4.223)	Lower 1/37 (2.7%) vs 16/41 (39.0%) (OR 0.06, 95% CI 0.008 to 0.48)
Verpoest etal. (2018)	205 patients (177 transfers) Age: 38.6 ± 1.4	191 patients (249 transfers) Age: 38.6 ± 1.4	Polar body	aCGH	No difference 50/205 (24%) vs 45/191(24%) (RR 1.06; 95% CI 0.75 to 1.50; P = 0.75) (per patient)	Lower 14/205 (7%) vs 27/191 (14%) (RR 0.48; 95% CI 0.26 to 0.90; P = 0.02)
Munné etal. (2019)	330 patients undergoing IVF with at least two blastocysts that could be biopsied Age: 33.7 ± 3.59	331 patients undergoing IVF with at least two blastocysts that could be biopsied Age: 33.8 ± 3.58	Blastocyst	NGS	No difference3 137/274 (50%) vs 143/313 (46%) (per ET) per ITT (per patient): 138/330 (41.8%) vs 144/331 (43.5%)	No difference 27/274 (9.9%) vs 30/313 (9.6%)
Yan etal. (2021)	606 women with three or more good-quality blastocysts Age: 29.1 ± 3.6	606 women with three or more good-quality blastocysts Age: 29.2 ± 3.5	Blastocyst	NGS	Lower (per patient) 458/606 (77.2%) vs 496/606 (81.8%) (absolute difference, −4.6 percentage points; 95% CI −9.2 to −0.0; P < 0.001)	Lower 8.7% and 12.6%, (RR 0.69; 95% CI 0.49 to 0.98)

¹Ongoing pregnancy (≥20 weeks gestational age).

²Ongoing pregnancy rate per randomized patient after the first ET.

³Ongoing pregnancy rate (OPR) at 20 weeks’ gestation per ET.

aCGH: array comparative genomic hybridization; ET: embryo transfer; LBR: live birth rate; NGS: next-generation sequencing; OR: odds ratio; RR: relative risk; RCT: randomized controlled trial; PGT-A: preimplantation genetic testing for aneuploidy; Age = years.