Figure 1.

Both genetic susceptibility and environmental triggers such as infections, drugs and trauma play important roles in developing psoriasis. Keratinocytes together with DC cells are responsible for the initial stage through the production of pro-inflammatory factors. T cells are believed to be in the center of accelerating the process of psoriasis as two main subtypes of T cells namely conventional adaptive T cells and innate-like T cells work together to maintain the inflammatory loop during the psoriasis.