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Panel 1 - Neuropathologist's viewpoint of in vivo models
| Be clear about what the model is actually modelling. What aspect of the human spectrum of SVD is being assessed? |
| Where possible, compare or relate animal model tissue-level observations to human tissues. Is the animal model observation relevant to the human disease? |
| SVD – even quite severe SVD – can be clinically silent |
| A “good” model need not have cognitive phenotypes |
| A SVD model needs some vascular pathology |
