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. 2023 Oct 24;14:1258469. doi: 10.3389/fmicb.2023.1258469

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Copyright © 2023 Ji, Tian, Shang and Jiang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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2K4L inhibited inflammatory response induced by A. baumannii in sepsis mice. (A–D) Effects of 2K4L on the production of TNF-α and IL-6 in the sepsis mice serum induced by MRAB 0227 and AB 22933; (E,F) proteins were extracted from mouse liver tissue at Days 2 and 7 of peptide treatment. Western blotting analysis of the effects of 2K4L on the expression of p-NF-κB and p-IκB; (G,H) western blotting analysis of the effects of 2K4L on the expression of p-JNK, p-ERK and p-p38. ^## (P < 0.01) indicates statistically significant differences between the MRAB 0227/AB 22933 group and control (0.9% NaCl). * (P < 0.05) and ^** (P < 0.01) indicate statistically significant differences between peptide and the MRAB 0227/AB 22933 group. The data are presented as the mean ± SEM (n = 3).