Fig. 7. Schematic diagram depicting the role of HA–DP in preserving lymphatic phenotypes. HA–DP was able to preserve key lymphatic markers, including Prox1, LYVE-1, podoplanin, and VEGFR3. When LECs are cultured on fibronectin coated plates, YAP/TAZ enter the nucleus and bind to the PROX-1 promoter, inhibiting its transcription, including its targets, such as LYVE-1, podoplanin, and VEGFR3. In contrast, culturing LECs on HA–DP coated plates enables YAP/TAZ to undergo cytoplasmic degradation, which subsequently enhance transcription of Prox1, including its targets, such as LYVE-1, podoplanin, and VEGFR3.
