Skip to main content
. 2023 Oct 14;26(11):108211. doi: 10.1016/j.isci.2023.108211

Figure 2.

Figure 2

GM6001 pre-treatment alleviated the damaged intracellular junctions through suppressing the shedding of syndecan-1 (SDC-1) and activation of STAT3

(A) GM6001 pre-treatment inhibiting the shedding of SDC-1 in the ischemia/reperfusion (I/R) mice, n = 6.

(B–D) The serum creatinine (SCr) and renal pathological injury were alleviated after GM6001 pre-treatment in the I/R mice, Bar = 50μm, n = 6.

(E and F) Protein expression of STAT3 and E-cadherin after inhibition of SDC-1 shedding in the I/R mice, n = 5–6.

(G) Histochemical staining of E-cadherin expression (n = 4) and TUNEL staining (n = 3) of apoptotic tubular epithelial cells in mice kidneys from the GM6001+I/R and DMSO+I/R group, Bar = 50μm.

(H) The statistical graph of the TUNEL result.

(I) The intracellular junctions between tubular epithelial cells in the I/R mice shown using TEM, n = 2, Bar = 1μm. ∗p < 0.05, ∗∗p < 0.01 vs. DMSO+I/R group.