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. 2023 Oct 14;26(11):108211. doi: 10.1016/j.isci.2023.108211

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© 2023 The Author(s)

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

The effect of tubule selective syndecan-1 (SDC-1) knockout on renal I/R injury, intracellular junctions and activation of STAT3

(A and B) The renal histopathological injury was aggravated in mild ischemia/reperfusion (I/R) injury in the SDC-1^fL/fl/Cre⁺ mice, Bar, 50μm, n = 4.

(C) Mild I/R injury could result in significantly increased serum creatinine (SCr) in the SDC-1^fL/fl/Cre⁺ mice, n = 4.

(D and E) The activation of STAT3 was detected in SDC-1^fL/fl/Cre⁺ mice after mild I/R injury, n = 3–4.

(F) The expression of E-cadherin was decreased in SDC-1^fL/fl/Cre⁺ I/R mice, n = 3–4.

(G and H) the apoptotic cells were increased by mild I/R injury in the SDC-1^fL/fl/Cre⁺ I/R mice, n = 3.

(I) The damaged intracellular junctions of tubular cells by mild I/R injury in SDC-1^fL/fL mice kidneys were detected by TEM, n = 2, Bar, 1μm. ∗p < 0.05.