REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
Anti-Syndecan-1 antibody [EPR6454]	Abcam	Cat# ab128936; RRID:AB_11150990
Beta Actin antibody	Genetxt	Cat#109639; RRID:AB_1949572
BAX Polyclonal antibody	Proteintech	Cat#50599-2-Ig; RRID:AB_2061561
Anti-Bcl-2 antibody	Abcam	Cat#ab182858; RRID: AB_2715467
Caspase 3/p17/p19 Polyclonal antibody	Proteintech	Cat# 19677-1-AP; RRID: AB_10733244
Anti-STAT3(phospho Y705) antibody [EP2147Y]	Abcam	Cat# ab76315; RRID:AB_1658549
Anti-STAT3 [EPR787Y] antibody	Abcam	Cat# ab68153; RRID:AB_2889877
Anti-Aquaporin 1 antibody [ERP11588(B)]	Abcam	Cat# ab168387; RRID:AB_2810992
Purified Mouse Anti-E-Cadherin	BD bioscience	Cat#: 610181; RRID: AB_397580
Biological samples
Human kidney samples	Zhongshan hospital, Fudan university	N/A
Chemicals, peptides, and recombinant proteins
Matrigel matrix	Corning	Cat#:354277
GM6001	Abcam	Cat#: ab120845
S3I-201	Selleck	Cat#: S1155
AG490	Selleck	Cat#: S1143
Trizol	Invitrogen	Cat#: 15596018
Critical commercial assays
PrimeScriptä RT Master Mix	Takara	Cat#: RR036A
TB Greenä Premix Ex Taqä II (Tli RNaseH Plus)	Takara	Cat#: RR820A
Lipofectamine 3000 Transfection Reagent	Invitrogen	Cat#: L3000001
Mouse SDC-1 ELISA kit	Diaclone	Cat#: 860.090.096
Pierce ECL Western blotting substrate	Thermo fisher Scientific	Cat#:32209
Quantichrom™ Creatinine Assay Kit	Bioassay System	Cat#: DICT-500
Experimental models: Organisms/strains
SDC-1flox/flox	Shanghai Southern Model Biological	N/A
Cdh16cre	Shanghai Southern Model Biological	N/A
Oligonucleotides
Primers see method details	This paper	N/A
Software and algorithms
ImageJ	ImageJ software	Version 1.51
Graphpad Prism	Graphpad software	Version
Photoshop	Adobe	N/A