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. 2023 Oct 31;32(5):313–327. doi: 10.5607/en23028

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Copyright © Experimental Neurobiology 2023

This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. 2 — CUS and F4 consumption changed 5-HT and tryptophan metabolic pathways in the serum and brain. (A) A simplified schematic diagram of tryptophan metabolic pathways. (B~H) Concentrations of tryptophan metabolites in serum. (B) Tryptophan. Unpaired Welch’s t-test; Control (n=16), CUS+Veh (n=9), CUS+F4 (n=8). (C) 5-HTP. Uncorrected Fisher’s LSD; Control (n=16), CUS+Veh (n=9), CUS+F4 (n=8). (D) 5-HT. Uncorrected Fisher’s LSD; Control (n=16), CUS+Veh (n=9), CUS+F4 (n=8). (E) 5-HIAA. Uncorrected Fisher’s LSD; Control (n=16), CUS+Veh (n=9), CUS+F4 (n=8). (F) Kynurenine. Uncorrected Fisher’s LSD; Control (n=16), CUS+Veh (n=9), CUS+F4 (n=8). (G) Kynurenic acid. Uncorrected Fisher’s LSD; Control (n=16), CUS+Veh (n=9), CUS+F4 (n=8). (H) Tryptamine. Unpaired Welch’s t-test; Control (n=16), CUS+Veh (n=9), CUS+F4 (n=8). (I~O) Concentrations of tryptophan metabolites in brain. (I) Tryptophan. Unpaired Welch’s t-test; Control (n=16), CUS+Veh (n=7), CUS+F4 (n=8). (J) 5-HTP. Uncorrected Fisher’s LSD; Control (n=16), CUS+Veh (n=7), CUS+F4 (n=8). (K) 5-HT. Uncorrected Fisher’s LSD; Control (n=16), CUS+Veh (n=7), CUS+F4 (n=8). (L) 5-HIAA. Unpaired Welch’s t-test; Control (n=16), CUS+Veh (n=7), CUS+F4 (n=8). (M) Kynurenine. Uncorrected Dunn’s test. Control (n=16), CUS+Veh (n=7), CUS+F4 (n=8). (N) Kynurenic acid. Uncorrected Dunn’s test; Control (n=16), CUS+Veh (n=7), CUS+F4 (n=8). (O) Tryptamine. Unpaired Welch’s t-test; Control (n=16), CUS+Veh (n=7), CUS+F4 (n=8); 5-HTP, 5-hydroxytryptophan; 5-HT, Serotonin; 5-HIAA, 5-Hydroxydindoleacetic acid. *p<0.05, **p<0.01, ***p<0.001, ****p<0.0001.