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. 2023 Oct 31;32(5):313–327. doi: 10.5607/en23028

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Copyright © Experimental Neurobiology 2023

This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. 4 — CUS-induced anhedonic behaviors were alleviated by Htr1a knockdown in the mPFC. (A) Experimental schedule. (B) Representative images of AAV injection site in the mPFC. Scale bar=1,000 μm (C) Efficiency of Htr1a knockdown (KD) by AAV expression in the mPFC. Mann-Whitney U test; Scramble (n=6), Htr1a KD (n=6). (D) Sucrose preference after CUS±Htr1a KD. Tukey’s test; No CUS+AAV-scramble (n=8), CUS+AAV-scramble (n=8), CUS+AAV-shHtr1a (n=8). (E) Body weight after CUS±Htr1a KD. Tukey’s test; No CUS+AAV-scramble (n=8), CUS+AAV-scramble (n=8), CUS+AAV-shHtr1a (n=8). *p<0.05, **p<0.01, ***p<0.001, ****p<0.0001, ns (not significant).