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. 2005 Mar 10;115(4):978–985. doi: 10.1172/JCI23043

Figure 2.

Figure 2

Prevention of PLK-1 expression and function by siRNA/cationic liposome complexes. (A) Comparison of the reduction of PLK-1 expression by 4 siRNAs. (B) Time-dependent inhibition of PLK-1 expression by PLK-1 siRNA 1412. (C) Dose-dependent inhibition of PLK-1 expression and accumulation of cyclin B1 by PLK-1 siRNA 1412. (D) Prevention of bipolar spindle formation by PLK-1 siRNA (100 nM, 24 hours). β-Tubulin staining, γ-tubulin staining, and Hoechst 33342 DNA staining of bladder cancer cells (UM-UC-3) are shown.