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. 2005 Mar 10;115(4):1030–1038. doi: 10.1172/JCI23962

Figure 2.

Figure 2

Effect of SCD1 ASOs on weight gain, body adiposity, and plasma metabolic parameters in C57/B6 mice on HFD. C57/B6 mice were given HFD and treated with ASO1, ASO2, or ASOctrl at 5 and 15 mpk twice a week for 9–10 weeks as described in Methods. Shown are the body weight (A) and food intake (B) of the animals measured weekly. Also shown are body composition (C), and postprandial plasma insulin (D) and glucose (E) measured at the end of the treatments. While ASO2 was only tested in the current experiment, similar results on ASO1 and ASOctrl were obtained in 2 experiments. *P < 0.05; **P < 0.01.