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. 2005 Mar 10;115(4):1030–1038. doi: 10.1172/JCI23962

Figure 3.

Figure 3

Effect of SCD1 ASO2 on oxygen consumption and physical activity of C57/B6 mice on HFD. Interval measurements of oxygen consumption and physical activity were done every 30 minutes for 24 hours on C57/B6 mice fed HFD and treated with ASO2 or ASOctrl at 15 mpk for 10 weeks as described in Methods. Shown are the volume of oxygen consumed (A) and the cumulative ambulatory xy counts (i.e., the number of times that light beams in the x and y axes were broken due to animal movement; B). Both oxygen consumption and physical activity are significantly higher in ASO2-treated mice than in ASOctrl-treated mice (P < 0.05).