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. 2023 Jul 20;25(11):2028–2041. doi: 10.1093/neuonc/noad126

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Figure 4. — Applicability of 7-HOX gene signature in the subtypes of IDHmut glioma with 1p/19q codeletion and without 1p/19q codeletion: (A) Overall survival shown using Kaplan–Meier diagram based on HOX gene methylation pattern (hypermethylation vs hypomethylation) in 1p/19q codeleted IDHmut glioma. (B) Kaplan–Meier survival analysis based on expression of HOX genes in 1p/19q codeleted IDHmut glioma. (C) Overall survival was shown using Kaplan–Meier diagram based on HOX gene methylation pattern (hypermethylation vs. hypomethylation) in non-codeleted IDHmut LGG. (D) Kaplan–Meier survival analysis based on expression of HOX genes in non-codeleted IDHmut glioma. (E) Kaplan–Meier diagram with the survival statistics of integrative RNA-methylation (iRM) subtypes of similar directionality of HOX gene methylation and HOX gene expression (iRM high and iRM low) in codeleted IDHmut glioma. (F) Kaplan–Meier diagram with the survival statistics of integrative RNA-methylation (iRM) subtypes of similar directionality of HOX gene methylation and HOX gene expression (iRM high and iRM low) in non-codeleted IDHmut glioma.