Table 1.
Patient Characteristics of IDH-Mutant Gliomas Based on University Health Network, The Cancer Genome Atlas, and DKFZ Cohorts.27 The CDKN2A Status is for the CDKN2A Homozygous Deletion.
| Characteristics | Cohorts | ||
|---|---|---|---|
| UHN | TCGA | DKFZ | |
| N = 99 | N = 419 | N = 211 | |
| Pathological grade | |||
| 2 | 29 (29.3%) | 221 (52.7%) | 54 (25.6 %) |
| 3 | 59 (59.6%) | 190 (45.3%) | 90 (42.7%) |
| 4 | 11 (11.1%) | 7 (1.7%) | 67 (31.8%) |
| Unknown | 0 | 1 (0.2%) | 0 |
| CDKN2A status | |||
| Retained | 76 (76.8%) | 397 (94.7%) | 173 (82%) |
| Lost | 23 (23.2%) | 22 (5.3%) | 38 (18%) |
| WHO 2021 grade | |||
| 2 | 26 (26.3%) | 108 (25.8%) | 54 (25.6 %) |
| 3 | 46 (46.5%) | 232 (55.4%) | 75 (35.5%) |
| 4 | 27 (27.3%) | 29 (6.9%) | 82 (38.9%) |
| G-CIMP status | |||
| High | 47 (47.5%) | 234 (55.8%) | 185 (87.7%) |
| Low | 7 (7.1%) | 12 (2.9%) | 26 (12.3%) |
| Codel | 45 (45.4%) | 172 (41.1%) | 0 |
| Unknown | 0 | 1 (0.2%) | 0 |
| Age (at diagnosis) | |||
| Median (range) | 39 (22–73) | 39 (14–75) | 36 (15–70) |
| Unknown | 0 | 2 | 5 |
| Survival (months) | |||
| Median (range) | 90.8 (2.5–227.2) | 25.8 (0–182.3) | 49.7 (0.23–268) |
| Unknown | 0 | 1 | 0 |