Fig. 7.

A Hierarchal clustering on 27 a priori selected genes which were differentially expressed between healthy volunteers (HV) and ICU patients at admission, identifying cluster for validation. B Differential gene expression in the validation cohort between ICU admission and discharge in ICU patients undergoing unilateral Functional Electrical Stimulation (FES) with the contralateral leg receiving standard care (SC). IL-18 = Interleukin-18; DGKD = Diacylglycerol Kinase Delta; MCAD = Acyl-CoA Dehydrogenase Medium Chain; PYGM = Glycogen phosphorylase; and UCP3 = Uncoupling Protein 3. Data are presented as fold change with gene expression normalized to patient’s admission values for each group, mean ± SEM