Table 2.
Baseline cognitive performance: symptomatic DIAD versus sEOAD
| Characteristic | DIAD | sEOAD | Significance level (P-value*) |
|---|---|---|---|
| Logical memory (immediate recall), mean (SD), n | 6.1 (4.6) n = 113 |
4.7 (4.3) n = 45 |
0.08 |
| Logical memory (delayed recall), mean (SD), n | 4.3 (4.5) n = 111 |
4.0 (4.3) n = 43 |
0.69 |
| Category fluency (vegetables), mean (SD), n | 9.3 (4.3) n = 101 |
6.7 (4.7) n = 43 |
<0.001 |
| Category fluency (animals), mean (SD), n | 15.3 (6.0) n = 113 |
10.5 (5.5) n = 101 |
<0.001 |
| Letter fluency, mean (SD), n | 10.6 (4.8) n = 99 |
11.8 (5.1) n = 35 |
0.54 |
| Digit span forward, mean (SD), n | 6.6 (2.5) n = 113 |
5.7 (2.4) n = 101 |
<0.01 |
| Digit span backward, mean (SD), n | 4.9 (2.3) n = 113 |
3.8 (2.2) n = 101 |
0.001 |
| Trail Making Test Part A, mean (SD), n | 54.9 (41.1) n = 106 |
81.6 (51.6) n = 66 |
<0.001 |
| Trail Making Test Part B, mean (SD), n | 147.7 (102.4) n = 86 |
207.8 (97.8) n = 47 |
<0.001 |
| Boston Naming Test, mean (SD), n | 23.6 (5.7) n = 106 |
22.7 (7.3) n = 43 |
0.27 |
| Digit symbol, mean (SD), n | 34.9 (19.1) n = 106 |
22.7 (13.9) n = 28 |
<0.001 |
Logical memory, category fluency, letter fluency, digit span, Boston Naming Test and digit symbol: lower scores indicating poorer cognitive performance. Trail Making Test scores: higher scores indicating poorer cognitive performance. *P-values were adjusted for baseline EYO, sex, education and APOE4 status. Significant differences are highlighted as bold values.