Table 3.
Estimated annual rate of change (standard error): symptomatic DIAD versus sEOAD by baseline EYO = 1, 5 and 10
| DIAD | sEOAD | |||||
|---|---|---|---|---|---|---|
| EYO | Rate of change | P-value* | Rate of change | P-value* | P-value* comparing DIAD versus sEOAD | |
| Cognitive Composite | 1 | −0.20 (0.06) | <0.001 | −0.31 (0.10) | <0.01 | 0.32 |
| 5 | −0.35 (0.07) | <0.001 | −0.28 (0.07) | <0.001 | 0.37 | |
| 10 | −0.54 (0.16) | <0.001 | −0.24 (0.16) | 0.15 | 0.17 | |
| CDR-SB, mean (SE) | 1 | 0.89 (0.29) | 0.003 | 1.36 (0.33) | <0.001 | 0.25 |
| 5 | 2.11 (0.32) | <0.001 | 1.57 (0.23) | <0.001 | 0.11 | |
| 10 | 3.63 (0.71) | <0.001 | 1.82 (0.54) | <0.001 | 0.03 | |
| MMSE mean (SE) | 1 | −1.30 (0.48) | 0.008 | −3.66 (0.60) | <0.001 | <0.01 |
| 5 | −3.03 (0.56) | <0.001 | −2.77 (0.42) | <0.001 | 0.67 | |
| 10 | −5.18 (1.24) | <0.001 | −1.67 (0.97) | 0.09 | 0.02 | |
| NPI-Q mean (SE) | 1 | 0.33 (0.83) | 0.69 | 1.32 (0.90) | 0.15 | 0.39 |
| 5 | 1.62 (1.03) | 0.12 | 0.72 (0.67) | 0.29 | 0.41 | |
| 10 | 3.22 (2.33) | 0.17 | −0.02 (1.64) | 0.99 | 0.24 | |
| Category fluency (animals), mean (SE) | 1 | −0.93 (0.49) | 0.06 | −1.19 (0.88) | 0.18 | 0.78 |
| 5 | −1.84 (0.65) | 0.01 | −0.77 (0.60) | 0.19 | 0.15 | |
| 10 | −2.98 (1.44) | 0.04 | −0.25 (1.44) | 0.86 | 0.16 | |
| Category fluency (vegetable), mean (SE) | 1 | −0.62 (0.37) | 0.11 | −0.62 (0.75) | 0.41 | 0.99 |
| 5 | −1.40 (0.51) | 0.01 | −1.65 (0.49) | 0.001 | 0.66 | |
| 10 | −2.37 (1.11) | 0.03 | −2.95 (1.13) | 0.01 | 0.71 | |
| Letter fluency, mean (SE) | 1 | −0.32 (0.37) | 0.40 | 2.63 (1.33) | 0.052 | 0.03 |
| 5 | −1.09 (0.56) | 0.06 | −1.41 (0.82) | 0.09 | 0.71 | |
| 10 | −2.05 (1.21) | 0.09 | −6.45 (2.29) | 0.01 | 0.08 | |
| Logical memory (immediate recall), mean (SE) | 1 | −0.52 (0.32) | 0.11 | −0.37 (0.82) | 0.65 | 0.85 |
| 5 | −1.00 (0.44) | 0.02 | −1.41 (0.53) | 0.01 | 0.49 | |
| 10 | −1.60 (0.94) | 0.09 | −2.71 (1.40) | 0.06 | 0.50 | |
| Logical memory (delayed recall), mean (SE) | 1 | −0.17 (0.28) | 0.55 | −0.05 (0.73) | 0.95 | 0.87 |
| 5 | −0.76 (0.39) | 0.05 | −1.84 (0.49) | <0.001 | 0.05 | |
| 10 | −1.50 (0.84) | 0.08 | −4.09 (1.28) | <0.001 | 0.089 | |
| Digit symbol, mean (SE) | 1 | −4.32 (1.37) | <0.001 | −5.97 (4.36) | 0.18 | 0.70 |
| 5 | −7.18 (1.89) | <0.001 | −4.19 (2.80) | 0.14 | 0.32 | |
| 10 | −10.75 (4.04) | <0.001 | −1.96 (7.01) | 0.78 | 0.28 | |
| Digit span forward, mean (SE) | 1 | −0.37 (0.19) | 0.06 | −0.51 (0.35) | 0.15 | 0.69 |
| 5 | −1.48 (0.25) | <0.001 | −0.62 (0.23) | 0.01 | 0.004 | |
| 10 | −2.87 (0.56) | <0.001 | −0.76 (0.57) | 0.18 | 0.01 | |
| Digit span backward, mean (SE) | 1 | −0.30 (0.14) | 0.04 | −0.08 (0.26) | 0.77 | 0.17 |
| 5 | −0.30 (0.21) | 0.17 | −0.77 (0.19) | <0.001 | 0.054 | |
| 10 | −0.29 (0.48) | 0.54 | −1.83 (0.47) | <0.001 | 0.02 | |
| Trail Making Test Part A, mean (SE) | 1 | 6.80 (3.81) | 0.081 | 2.72 (9.58) | 0.78 | 0.68 |
| 5 | 22.00 (4.99) | <0.001 | 10.48 (5.74) | 0.07 | 0.07 | |
| 10 | 41.00 (11.02) | <0.001 | 20.18 (14.67) | 0.17 | 0.24 | |
| Trail Making Test Part B, mean (SE) | 1 | 17.55 (9.12) | 0.06 | −41.65 (25.77) | 0.11 | 0.03 |
| 5 | 21.77 (15.70) | 0.17 | 26.81 (16.62) | 0.11 | 0.78 | |
| 10 | 27.05 (35.80) | 0.45 | 112.39 (41.84) | 0.01 | 0.11 | |
| Boston Naming Test, mean (SE) | 1 | −0.79 (0.55) | 0.15 | −1.72 (1.49) | 0.25 | 0.54 |
| 5 | −2.11 (0.68) | <0.001 | −2.74 (0.86) | <0.01 | 0.51 | |
| 10 | −3.75 (1.45) | 0.01 | −4.01 (2.29) | 0.08 | 0.92 | |
Logical memory, category fluency, letter fluency, digit span, Boston Naming Test and digit symbol: lower scores indicating poorer cognitive performance. Trail Making Test scores: higher scores indicating poorer cognitive performance. Cognitive composite is the mean of the standardized scores for animal naming, delayed recall, digit symbol and MMSE tests. *P-values were adjusted for baseline EYO, sex, education and APOE4 status. Significant differences are highlighted as bold values.