Fig. 1.

Unrestrained peroxidation of membrane lipids drives ferroptotic cell death. Inhibition of both nonenzymatic lipid peroxidation (autoxidation) and enzyme-catalyzed lipid peroxidation may suppress ferroptosis. Newly reported FerroLOXins have been designed to inhibit oxidation of phosphatidylethanolamine lipids by a 15-LOX2/PEBP1 complex. Since FerroLOXins are aromatic amines, such as the canonical RTA inhibitors ferrostatin-1, liproxstatin-1, and PTG-00, they may also prevent nonenzymatic lipid peroxidation.