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The cryo-EM structure of pSERT in complex with (+)-methamphetamine or cocaine. (A) Overall structure of the (+)-methamphetamine complex in the outward-open conformation, shown in cartoon representation. (B) Cartoon representation of the cocaine complex in the outward-occluded conformation. (+)-methamphetamine, cocaine, cholesteryl hemisuccinate (CHS), and n-dodecyl-β-D-maltoside (DDM) are shown in space-filling representations.
