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Ligands occupy the central site. (A) Close-up view of (+)-methamphetamine in the binding pocket with hydrogen bonds shown as dashed lines. (B) Slice view of pSERT in complex with (+)-methamphetamine. (C) Cocaine interactions within the central binding site. A hydrogen bond between cocaine and D135 is indicated with a dashed line. (D) Slab views of the extracellular cavity of pSERT in complex with cocaine. Shown are residue numbers for pSERT and in parenthesis, for hSERT.
