Figure 2.

(A) Riboflavin transferred through corneal epithelial cells. The DODAP/ISA, MedioCROSS, and Arg/LA formulations were applied to LabCyte CORNEA-MODEL tissue, and the concentration of transferred riboflavin was measured by HPLC. Data are shown as average ± SD (n = 3). *P < 0.05, MedioCROSS versus Arg//LA; **P < 0.05, DODAP/ISA versus Arg/LA; +P < 0.05, MedioCROSS versus DODAP/ISA. (B) TEER values after incubation of DODAP/ISA, MedioCROSS, and Arg/LA formulations for 24 hours. Data are shown as average ± SD (n = 3). *P < 0.05, Arg//LA versus MedioCROSS; **P < 0.05, DODAP/ISA versus MedioCROSS.