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. 2023 Jul 10;120(29):e2303740120. doi: 10.1073/pnas.2303740120

Fig. 6.

Fig. 6.

Impact of KRAS knockdown on tumor growth, and angiogenesis in various antibody-treated CRC tumors. (A) Tumor growth rates of HCT116 KRAS mutant and shKRAS CRC tumors (n = 5 to 8 tumors per group). (B) Tumor growth rates of vehicle-, anti-VEGF-, anti-ANG2-, anti-VEGF plus anti-ANG2-treated HCT116 KRAS mutant and shKRAS CRC tumors (n = 5 to 8 tumors per group). Vehicle-treated controls are the same as those in A. (C and D) CD31+ tumor microvessels (red) and NG2+ pericytes (green) in various antibody-treated HCT116 KRAS mutant (C) and shKRAS (D) CRC tumors. (E and F) Quantification of microvessels and pericyte coverage in various antibody-treated HCT116 KRAS mutant (E) and shKRAS (F) CRC tumors (n = 10 fields per group). All data represent mean ± SEM. (Scale bar, 50 μm.) Statistical analysis was performed using two-sided unpaired t tests (A and B) and one-way ANOVA followed by Tukey’s multiple comparison tests (E and F). *P < 0.05, **P < 0.01, ***P < 0.001. N.S., not significant.