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PafA catalysis and binding. (A) PafA active site and catalytic cycle showing helices containing the nucleophilic threonine (green) and active-site residues K162 and R164 (orange). (B–D) Schematics of ground state (B), transition state (C), and transition state analog-bound state (D). The semitransparent plane contains the equatorial oxygen atoms expected in the trigonal bipyramidal geometry of the transition state and of bound analogs.
