. 2023 Nov 7;18(11):e0293842. doi: 10.1371/journal.pone.0293842

Table 2. Prognostic effects of serial changes in biomarkers since admission.

n = 381	30-day mortality			60-day mortality			ICU transfer			Overall Survival
n = 381	OR	95% CI	P	OR	95% CI	P	OR	95% CI	P	HR	95% CI	P
CRP (mg/L) at Day 1	1.01	1.00 – 1.01	0.001	1.01	1.00 – 1.01	<0.001	1.02	1.01 – 1.02	<0.001	1.01	1.00 – 1.01	<0.001
Slope of CRP	1.12	1.03 – 1.21	0.008	1.12	1.04 – 1.22	0.005	1.42	1.25 – 1.65	<0.001	1.07	1.01 – 1.14	0.02
Age	1.09	1.06 – 1.12	<0.001	1.08	1.06 – 1.11	<0.001	1.01	0.98 – 1.03	0.63	1.08	1.05 – 1.10	<0.001
Female vs. Male	0.58	0.30 – 1.07	0.09	0.56	0.30 – 1.01	0.06	0.71	0.36 – 1.38	0.32	0.71	0.43 – 1.16	0.17
Ever smoker vs. never smoker	0.74	0.39 – 1.39	0.36	0.80	0.43 – 1.48	0.48	0.50	0.23 – 1.04	0.07	0.80	0.49 – 1.32	0.39
Surge 2 vs. 1	1.31	0.69 – 2.49	0.40	1.48	0.79 – 2.76	0.22	0.91	0.44 – 1.82	0.78	1.35	0.81 – 2.24	0.25
Hispanic vs. Non-Hispanic	1.04	0.49 – 2.17	0.91	0.97	0.47 – 1.98	0.94	0.96	0.43 – 2.10	0.91	0.90	0.50 – 1.62	0.72
n = 377	30-day mortality			60-day mortality			ICU transfer			Overall Survival
n = 377	OR	95% CI	P	OR	95% CI	P	OR	95% CI	P	HR	95% CI	P
D-dimer (ug/mL) at Day 1	1.00	1.00 – 1.00	0.36	1.00	1.00 – 1.00	0.18	1.00	1.00 – 1.00	0.02	1.00	1.00 – 1.00	0.31
Slope of D-dimer	1.00	1.00 – 1.00	0.82	1.00	1.00 – 1.00	0.68	1.01	1.00 – 1.01	0.01	1.00	1.00 – 1.00	0.94
Age	1.09	1.06 – 1.12	<0.001	1.08	1.05 – 1.11	<0.001	1.01	0.99 – 1.03	0.55	1.07	1.05 – 1.10	<0.001
Female vs. Male	0.55	0.29 – 1.05	0.07	0.57	0.30 – 1.05	0.07	0.99	0.53 – 1.84	0.98	0.67	0.40 – 1.12	0.13
Ever smoker vs. never smoker	0.69	0.35 – 1.32	0.26	0.73	0.39 – 1.36	0.33	0.60	0.29 – 1.18	0.15	0.73	0.44 – 1.24	0.25
Surge 2 vs. 1	0.82	0.43 – 1.54	0.54	1.01	0.55 – 1.84	0.97	0.62	0.31 – 1.21	0.17	0.98	0.60 – 1.60	0.93
Hispanic vs. Non-Hispanic	0.74	0.33 – 1.61	0.47	0.80	0.37 – 1.66	0.56	1.07	0.53 – 2.15	0.86	0.80	0.42 – 1.52	0.49
n = 429	30-day mortality			60-day mortality			ICU transfer			Overall Survival
n = 429	OR	95% CI	P	OR	95% CI	P	OR	95% CI	P	HR	95% CI	P
Platelet count (1000/mm3) at Day 1	0.99	0.99 – 1.00	0.001	0.99	0.99 – 1.00	<0.001	1.00	0.99 – 1.00	0.04	1.00	0.99 – 1.00	0.001
Slope of platelet	0.94	0.92 – 0.97	<0.001	0.94	0.91 – 0.96	<0.001	0.96	0.94 – 0.99	0.01	0.96	0.94 – 0.97	<0.001
Age	1.06	1.04 – 1.08	<0.001	1.06	1.04 – 1.08	<0.001	1.00	0.98 – 1.02	0.83	1.05	1.03 – 1.07	<0.001
Female vs. Male	0.55	0.31 – 0.97	0.04	0.57	0.32 – 0.99	0.05	0.77	0.43 – 1.37	0.38	0.78	0.50 – 1.21	0.26
Ever smoker vs. never smoker	0.92	0.52 – 1.63	0.79	0.98	0.56 – 1.72	0.95	0.62	0.32 – 1.17	0.14	0.88	0.57 – 1.37	0.58
Surge 2 vs. 1	1.04	0.60 – 1.79	0.88	1.23	0.72 – 2.09	0.44	0.72	0.39 – 1.29	0.27	1.20	0.80 – 1.80	0.38
Hispanic vs. Non-Hispanic	1.34	0.67 – 2.63	0.40	1.40	0.72 – 2.71	0.31	1.29	0.64 – 2.59	0.47	1.14	0.67 – 1.93	0.63
n = 431	30-day mortality			60-day mortality			ICU transfer			Overall Survival
n = 431	OR	95% CI	P	OR	95% CI	P	OR	95% CI	P	HR	95% CI	P
WBC count (1000/mm3) at Day 1	1.05	1.01 – 1.10	0.01	1.05	1.01 – 1.09	0.02	1.06	1.01 – 1.13	0.03	1.01	0.99 – 1.03	0.25
Slope of WBC	3.85	1.90 – 8.05	<0.001	2.91	1.47 – 5.87	0.002	9.43	2.92 – 34.65	<0.001	1.99	1.24 – 3.20	0.004
Age	1.07	1.05 – 1.10	<0.001	1.07	1.04 – 1.09	<0.001	1.00	0.98 – 1.02	0.84	1.06	1.04 – 1.08	<0.001
Female vs. Male	0.51	0.28 – 0.89	0.02	0.52	0.30 – 0.89	0.02	0.90	0.49 – 1.63	0.72	0.68	0.44 – 1.05	0.09
Ever smoker vs. never smoker	0.78	0.44 – 1.37	0.39	0.85	0.49 – 1.45	0.55	0.66	0.34 – 1.27	0.22	0.76	0.49 – 1.18	0.22
Surge 2 vs. 1	0.81	0.46 – 1.41	0.46	1.07	0.63 – 1.81	0.81	0.45	0.23 – 0.87	0.02	1.07	0.70 – 1.63	0.75
Hispanic vs. Non-Hispanic	0.89	0.45 – 1.74	0.74	0.91	0.47 – 1.72	0.77	0.93	0.46 – 1.86	0.85	0.87	0.51 – 1.50	0.63