Table 1.
Demographic and clinical data for the different study groups
| aMCI (n = 524) | ADD (n = 285) | |||||
|---|---|---|---|---|---|---|
| AD-like (n = 413) | LB-like (n = 111) | AD-like versus LB-like | AD-like (n = 247) | LB-like (n = 38) | AD-like versus LB-like | |
| Age, years | 74.6 ± 6.9 | 73.4 ± 8.2 | d = −0.21 P = 0.12 | 75.2 ± 8.1 | 75.0 ± 7.5 | d = −0.02 P = 0.87 |
| Male/female, % | 60/40 | 65/35 | P = 0.38 | 61/39 | 58/42 | P = 0.72 |
| Education, years | 16.0 ± 2.7 | 16.3 ± 2.7 | d = 0.10 P = 0.34 | 15.4 ± 2.8 | 15.2 ± 2.5 | d = −0.09 P = 0.59 |
| APOE ɛ4, −−/+−/++, % | 49/40/11 | 51/39/10 | P = 0.91 | 32/47/21 | 37/49/14 | P = 0.70 |
| MMSE | 27.4 ± 1.9 | 27.7 ± 1.6 | d = 0.15 P = 0.16 | 23.1 ± 2.2 | 23.1 ± 2.7 | d = 0.02 P = 0.90 |
| ADNI-MEM | 0.0 ± 0.6 | 0.4 ± 0.7 | d = 0.50 P < 0.001 a | −0.9 ± 0.5 | −0.8 ± 0.5 | d = 0.22 P = 0.21 |
| ADNI-EF | 0.1 ± 0.9 | 0.2 ± 0.9 | d = 0.14 P = 0.17 | −0.9 ± 0.9 | −1.5 ± 0.9 | d = −0.59 P < 0.001 a |
| Δ(MEM-EF) | 0.0 ± 0.8 | 0.3 ± 0.8 | d = 0.35 P = 0.01 a | −0.26 ± 0.8 | 0.46 ± 0.8 | d = 0.85 P < 0.001 a |
Patients are grouped by clinical diagnosis (aMCI versus ADD) and by FDG-PET classification (AD-like versus LB-like). AD = Alzheimer’s disease; ADD = Alzheimer’s disease dementia; aMCI = amnestic mild cognitive impairment; LB = Lewy body; MMSE = Mini-Mental State Examination; MEM = memory; EF = executive function.
Significantly different at P < 0.05 when compared to the AD-like group.