Table 2.
Comparing regional 11C-SL25.1188 VT between patients with TBI and healthy controls
| ROI | 11C-SL25.1188 VTa | Effect sizeb | Per cent differencec | Mean difference (95% CI) | P-valued | |
|---|---|---|---|---|---|---|
| Patients (n = 29) |
Healthy (n = 29) |
|||||
| PFC | 33.06 (4.48) | 29.00 (3.91) | 1.03 | 14.00 | 4.07 (1.81–6.32) | 0.00064 |
| DLPFC | 33.20 (4.58) | 29.37 (3.64) | 1.05 | 13.04 | 3.83 (1.66–6.01) | 0.00084 |
| VLPFC | 30.03 (4.04) | 26.76 (3.67) | 0.89 | 12.22 | 3.27 (1.24–5.30) | 0.0021 |
| MPFC | 37.65 (4.80) | 33.67 (4.36) | 0.91 | 11.82 | 3.98 (1.57–6.40) | 0.0017 |
| OFC | 31.49 (4.51) | 26.92 (4.84) | 0.94 | 16.98 | 4.57 (2.11–7.03) | 0.00046 |
| Temporal cortex | 32.68 (4.01) | 28.89 (3.78) | 0.98 | 13.12 | 3.79 (1.71–5.87) | 0.00058 |
| Parietal cortex | 32.38 (4.45) | 28.69 (3.87) | 0.93 | 12.86 | 3.69 (1.50–5.89) | 0.0014 |
| Occipital cortex | 28.38 (3.62) | 24.51 (3.33) | 1.14 | 15.79 | 3.87 (2.02–5.73) | 0.00010 |
| Hippocampus | 37.90 (4.37) | 32.24 (5.64) | 1.00 | 17.56 | 5.66 (3.01–8.32) | <0.0001 |
| Midbrain | 37.66 (4.20) | 32.70 (5.90) | 0.84 | 15.17 | 4.96 (2.26–7.65) | 0.00051 |
| ACC | 39.28 (5.01) | 36.82 (5.12) | 0.48 | 6.68 | 2.46 (–0.21–5.12) | 0.070 |
| Dorsal putamen | 49.21 (6.83) | 45.53 (6.63) | 0.56 | 8.08 | 3.38 (0.14–7.22) | 0.042 |
| Ventral striatum | 60.24 (9.15) | 56.47 (11.59) | 0.33 | 6.68 | 3.77 (–1.73–9.26) | 0.18 |
| Thalamus | 55.19 (7.80) | 49.05 (7.41) | 0.83 | 12.52 | 6.14 (2.14–10.15) | 0.0033 |
ACC = anterior cingulate cortex; CI = confidence interval; DLPFC = dorsolateral prefrontal cortex; MPFC = medial prefrontal cortex; OFC = orbitofrontal cortex; PFC = prefrontal cortex; ROI = region of interest; TBI = traumatic brain injury; VLPFC = ventrolateral prefrontal cortex; VT = total distribution volume.
Mean (standard deviation, SD).
(Mean of patients with TBI − Mean of healthy controls) / SD of healthy controls.
[(Mean of patients with TBI − Mean of healthy controls) / Mean of healthy controls] × 100.
ANOVA.