Figure 7.

Cerenkov radiation induced therapy mediated by radionuclide activated SPNs. (a) Therapeutic response was monitored by measuring the relative tumor volume in Balb/c mice bearing 4T1 tumors (n=3–5). Study treatment groups were PBS, MEP5 (IT), ⁸⁹Zr-DFO-MEP5 (IV), ⁸⁹Zr-DFO-TPP NPs (IT), and ⁸⁹Zr-DFO-MEP5 (IT). (b) Body weights were measured to evaluate treatment toxicity. (c) Kaplan-Meier curves demonstrating animal survival for 14 days after treatment. (d) Photograph of tumors extracted from the mice at the end of the study.