Table 4.
Time versus plasma concentrations (ng/mL) profile of CBD and metabolites, CBD-7-COOH and 7-OH-CBD, in plasma after IV administration of 1 mg control CBD
| Time | Rat 5 | Rat 6 | Rat 7 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| CBD | CBD-7-COOH | 7-OH-CBD | CBD | CBD-7-COOH | 7-OH-CBD | CBD | CBD-7-COOH | 7-OH-CBD | |
| 0 min | BLQ | BLQ | BLQ | BLQ | BLQ | BLQ | BLQ | BLQ | BLQ |
| 5 min | 842 | 306 | BLQ | 849 | 546 | 40.1 | 563 | 428 | 124 |
| 10 min | 588 | 477 | BLQ | 969 | 175 | BLQ | 743 | 553 | 212 |
| 15 min | 484 | 243 | BLQ | 641 | 310 | BLQ | 670 | 880 | BLQ |
| 30 min | 202 | 678 | BLQ | 203 | 743 | BLQ | 391 | 589 | 33.6 |
| 1 h | 117 | 178 | BLQ | 154 | 225 | BLQ | 142 | 158 | 30.3 |
| 2 h | 41.9 | 65.4 | 13.3 | 62.4 | 66.6 | BLQ | 93.3 | 119 | 17.2 |
| 4 h | 15.4 | 20.1 | BLQ | 21.9 | 38.9 | BLQ | 54.6 | 63.3 | BLQ |
| 6 h | 10.3 | BLQ | BLQ | 8.66 | 23.3 | BLQ | 28.1 | BLQ | BLQ |
| 24 h | BLQ | 12.7 | BLQ | 7.54 | BLQ | BLQ | N/A | N/A | N/A |
Below limit of quantitation (BLQ), lower limits of quantitation (LLOQ): CBD 5.6 ng/mL, CBD-7-COOH 5.0 ng/mL, 7-OH-CBD 5.0 ng/mL.
N/A, data not available.