Fig 3.

Inflammatory markers gene and protein expression levels decreased treatment with MESD extract in mice with DSS-induced colitis.

mRNA levels of (A) adhesion G Protein-Coupled Receptor E1 (Adgre1) and (B) interleukin-1β (Il-1β), (C) interleukin-6 (Il-6) and (D) tumor necrosis factor- α (Tnf-α) in DSS-induced mice colon tissue. The expression of inflammatory cytokines, (E) interleukin-1β (IL-1β), and (F) interleukin-6 (IL-6), in colon tissue of DSS-induced mice, based on ELISA assay. (G) The protein expression levels of inflammation-related markers, including COX-2 and NFκB pathway in mice colon tissue of DSS-induced colitis. All data are presented as mean ± SEM, with significant differences at p <0.05.