Extended Data Fig. 6. Additional GSFA results on CD8+ T cell CROP-seq dataset.
a) Estimated effects of gene perturbations on all factors inferred by GSFA within stimulated T cells. The size of a dot represents the PIP of association; the color represents the effect size. b) Similar to a) but estimated within unstimulated T cells. c) Loading of selected marker genes on all factors. The size of a dot represents the gene PIP in a factor and the color represents the gene weight (magnitude of contribution) in a factor. d–f) Estimated effects of perturbations on marker genes in stimulated T cells with DESeq2 (d), MAST (e), and SCEPTRE (f). Sizes of the dots represent FDR bins; colors of the dots represent the DESeq2 log2 fold change estimates, the MAST log fold change estimates, and the SCEPTER log fold change estimates, respectively.