Extended Data Fig. 8. Additional GSFA results on LUHMES CROP-seq dataset.
a) Estimated effects of gene perturbations on all factors inferred by GSFA. The size of a dot represents the PIP of association; the color represents the effect size. b) Loading of neuronal marker genes on all factors. The size of a dot represents the gene PIP in a factor and the color represents the gene weight (magnitude of contribution) in a factor. c) Heatmap of selected GO ‘biological process’ terms and their folds of enrichment in DEGs detected by GSFA (LFSR < 0.05). d–f) Estimated effects of perturbations on marker genes in LUHMES with DESeq2 (d), MAST (e), and SCEPTRE (f). Sizes of the dots represent FDR bins; colors of the dots represent the DESeq2 log2 fold change estimates, the MAST log fold change estimates, and the SCEPTER log fold change estimates, respectively.