Table 1. Comparison between Botox and anti-CGRP.

Botox: OnabotulinumtoxinA; Anti-CGRP: Calcitonin gene-related peptide antibodies

Table created by author Manoj Pallapothu

Features	Botox	Anti-CGRP
Admission	Physician administered every 3 months	Self-administered every month
Pain reduction	✔	✔
Initiation	10-14 days	1 month
Adverse effects	Muscle weakness, ptosis, and neck pain	Constipation, rash, pruritus, and fatigue
Compliance	More	Less
Examples	—	Erenumab, Eptinezumab, Fremanezumab