Table 2.
Results of the inspection of the structural models of the 114 predicted zinc(II) proteins lacking an experimental structure.a
| Unreliable | Good/partial match | Perfect match | Total | |
|---|---|---|---|---|
| Homologs with zinc | 7 (15%) | 7 (15%) | 32 (70%) | 46 |
| Homologs with different metals | 7 (44%) | 4 (25%) | 5 (31%) | 16 |
| Apo homologs | 10 (77%) | 3 (23%) | n.a. | 13 |
| Distant homologs | n.a. | 2 (25%) | 6 (75%) | 8 |
| No homologs or no corresponding region | 7 (23%) | 13 (42%) | 11 (35%) | 31 |
| Total | 32 (28%) | 28 (24%) | 54 (47%) | 114 |
a
Distant homologs are the proteins identified by BLAST in the PDB with an e-value > 10−5 or a sequence identity to the yeast protein of interest <30%. Partial matches occur when at least two predicted metal-binding residues overlapped properly in the structural comparison, as opposed to complete matches, which occurred when all predicted metal-binding residues overlapped correctly.