Table 9.
Effects of antibiotics and amino acids on pig antioxidant activity and oxidative/nitrosative damage1
Item2 | ATB−3 | ATB+4 | SEM | P-value | ||||
---|---|---|---|---|---|---|---|---|
18.5% CP5 | 13.0% CP6 | 18.5% CP5 | 13.0% CP6 | ATB | CP | CP × ATB | ||
66 d of age | ||||||||
CAT, U/ml | 275.6 | 275.5 | 273.0 | 277.0 | 7.85 | 0.947 | 0.816 | 0.804 |
SOD, U/ml | 161.7 | 167.7 | 161.0 | 169.0 | 7.64 | 0.964 | 0.364 | 0.894 |
GSH, U/ml | 12.09 | 11.90 | 12.00 | 12.16 | 1.03 | 0.936 | 0.988 | 0.873 |
FRAP, µmol/ml | 1.68 | 1.64 | 1.69 | 1.59 | 0.06 | 0.761 | 0.290 | 0.634 |
PC, nmol/ml | 9.75 | 12.00 | 8.84 | 8.39 | 0.63 | 0.004 | 0.213 | 0.065 |
NO, nmol/ml | 6.05 | 4.35 | 4.55 | 3.54 | 0.87 | 0.235 | 0.163 | 0.724 |
MDA, nmol/ml | 2.20 | 2.16 | 2.12 | 2.11 | 0.06 | 0.379 | 0.692 | 0.815 |
87 d of age | ||||||||
CAT, U/ml | 306.3 | 291.6 | 308.9 | 295.3 | 11.51 | 0.785 | 0.228 | 0.960 |
SOD, U/ml | 183.9 | 184.3 | 173.1 | 182.4 | 9.34 | 0.520 | 0.619 | 0.650 |
GSH, U/ml | 12.32 | 9.91 | 10.23 | 12.22 | 0.83 | 0.893 | 0.802 | 0.012 |
FRAP, µmol/ml | 1.83a | 1.84a | 1.90a | 1.75b | 0.03 | 0.853 | 0.035 | 0.014 |
PC, nmol/ml | 7.79 | 7.87 | 8.38 | 7.24 | 0.56 | 0.967 | 0.390 | 0.326 |
NO, nmol/ml | 3.83 | 3.61 | 3.60 | 2.91 | 0.68 | 0.648 | 0.664 | 0.618 |
MDA, nmol/ml | 1.72 | 1.80 | 1.75 | 1.67 | 0.06 | 0.474 | 0.946 | 0.273 |
1Experimental medicated diets (ATB +) were fed from 59 to 73 d old. In the post-medicated period, all pigs were fed their respective crude protein (CP) control diets from 73 to 87 d of age.
2FRAP, ferric reducing antioxidant plasma; CAT, catalase; GSH, glutathione; SOD, superoxide dismutase; PC, protein carbonyl; NO, nitric oxide; MDA, malondialdehyde.
3ATB -, diet without antibiotics.
4ATB +, diet with 100 mg/kg tiamulin and 506 mg/kg oxytetracycline.
518.5% CP, diet with 18.5% of CP.
613.0
% CP, diet with 13.0% of CP.
a‐
bMeans with different superscripts within a row differ (P < 0.05).