Skip to main content
. 2023 Oct 16;101:skad357. doi: 10.1093/jas/skad357

Table 9.

Effects of antibiotics and amino acids on pig antioxidant activity and oxidative/nitrosative damage1

Item2 ATB−3 ATB+4 SEM P-value
18.5% CP5 13.0% CP6 18.5% CP5 13.0% CP6 ATB CP CP × ATB
66 d of age
CAT, U/ml 275.6 275.5 273.0 277.0 7.85 0.947 0.816 0.804
SOD, U/ml 161.7 167.7 161.0 169.0 7.64 0.964 0.364 0.894
GSH, U/ml 12.09 11.90 12.00 12.16 1.03 0.936 0.988 0.873
FRAP, µmol/ml 1.68 1.64 1.69 1.59 0.06 0.761 0.290 0.634
PC, nmol/ml 9.75 12.00 8.84 8.39 0.63 0.004 0.213 0.065
NO, nmol/ml 6.05 4.35 4.55 3.54 0.87 0.235 0.163 0.724
MDA, nmol/ml 2.20 2.16 2.12 2.11 0.06 0.379 0.692 0.815
87 d of age
CAT, U/ml 306.3 291.6 308.9 295.3 11.51 0.785 0.228 0.960
SOD, U/ml 183.9 184.3 173.1 182.4 9.34 0.520 0.619 0.650
GSH, U/ml 12.32 9.91 10.23 12.22 0.83 0.893 0.802 0.012
FRAP, µmol/ml 1.83a 1.84a 1.90a 1.75b 0.03 0.853 0.035 0.014
PC, nmol/ml 7.79 7.87 8.38 7.24 0.56 0.967 0.390 0.326
NO, nmol/ml 3.83 3.61 3.60 2.91 0.68 0.648 0.664 0.618
MDA, nmol/ml 1.72 1.80 1.75 1.67 0.06 0.474 0.946 0.273

1Experimental medicated diets (ATB +) were fed from 59 to 73 d old. In the post-medicated period, all pigs were fed their respective crude protein (CP) control diets from 73 to 87 d of age.

2FRAP, ferric reducing antioxidant plasma; CAT, catalase; GSH, glutathione; SOD, superoxide dismutase; PC, protein carbonyl; NO, nitric oxide; MDA, malondialdehyde.

3ATB -, diet without antibiotics.

4ATB +, diet with 100 mg/kg tiamulin and 506 mg/kg oxytetracycline.

518.5% CP, diet with 18.5% of CP.

613.0

% CP, diet with 13.0% of CP.

a

bMeans with different superscripts within a row differ (P < 0.05).