Figure 1.

Results from MAGMA gene-set analysis of MEF2C gene-sets using GWAS data. (A) Results from the initial analysis of MEF2C gene-sets using GWAS data for SCZ, IQ and EA. The DEGs_Direct_Neuron gene-set was significantly enriched for common genetic variation associated with IQ and EA. (B, C) Post-hoc results based on these two significant results observed in the initial analysis. DEGs_Direct_Neuron was used to create two more gene-sets based on whether genes were up or down regulated upon MEF2C disruption. Each of the three gene-sets were tested for enrichment of common genetic variation associated with IQ (B) and EA (C), conditioning on brain elevated genes and cortical neuron elevated genes. The vertical lines show the significance threshold using the Bonferroni method to correct for the nine initial tests (P = 0.0056). Full results are detailed in Supplementary Table 4.