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. 2023 Aug 11;32(22):3153–3165. doi: 10.1093/hmg/ddad135

Figure 1.

Figure 1

Podocyte interactome shows interplay of YAP and TAZ with nuclear transport proteins. Volcano plots showing the interactors of YAP (A) and TAZ (B) in immortalized podocytes (hsMPs) overexpressing 3xFLAG.YAP or 3xFLAG.TAZ. Logarithmized ratios are plotted against the negative logarithmic P-value of the Student’s t-test. Data points with a P-value < 0.05 are printed bold (above dashed line). Known interactors are highlighted and labeled. (C) Venn diagram indicating numerical YAP and TAZ interactors overlapping with mouse podocyte proteome from Rinschen et al. (33). (d) Scatter plot combining the interactors of YAP and TAZ, with shared interactors (P-value for YAP and TAZ < 0.05) highlighted. Proteins of the nuclear-shuttling machinery are labeled and highlighted when related to FSGS. Dot plot showing proteins of nuclear shuttling machinery that are shared interactors by YAP and TAZ.