Figure 6.

NUP205 is critical for nuclear shuttling of YAP in healthy podocytes. (A) In a healthy podocyte, NUP205 is located at the nuclear membrane as part of the nuclear pore complex where YAP and TAZ can shuttle between the cytoplasm and the nucleus. (B) In the diseased podocyte lacking proper NUP205 expression, the nuclear translocation of YAP and TAZ is disrupted. YAP and TAZ are “trapped” in the cytoplasm resulting in a reduced nuclear transcriptional activity. (C) TAZ expression is crucial for NUP205 expression in podocytes. Reduced TAZ expression leads to reduced NUP205 expression, which then results in a shift of YAP localization. Created with BioRender.com.